LYMFASIM, a simulation model for predicting the impact of lymphatic filariasis control: quantification for African villages
Identifieur interne : 006E26 ( Main/Exploration ); précédent : 006E25; suivant : 006E27LYMFASIM, a simulation model for predicting the impact of lymphatic filariasis control: quantification for African villages
Auteurs : Wilma A. Stolk [Pays-Bas] ; Sake J. De Vlas [Pays-Bas] ; Gerard J. J. M. Borsboom [Pays-Bas] ; J. Dik F. Habbema [Pays-Bas]Source :
- Parasitology [ 0031-1820 ] ; 2008.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Afrique (épidémiologie), Animaux, Anopheles (parasitologie), Enfant, Enfant d'âge préscolaire, Filaricides (administration et posologie), Filaricides (pharmacologie), Filariose lymphatique (), Filariose lymphatique (épidémiologie), Humains, Logiciel, Modèles biologiques, Nourrisson, Nouveau-né, Répartition par âge, Simulation numérique, Sujet âgé, Sujet âgé de 80 ans ou plus, Vecteurs insectes (parasitologie).
- MESH :
- administration et posologie : Filaricides.
- parasitologie : Anopheles, Vecteurs insectes.
- pharmacologie : Filaricides.
- épidémiologie : Afrique, Filariose lymphatique.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Enfant d'âge préscolaire, Filariose lymphatique, Humains, Logiciel, Modèles biologiques, Nourrisson, Nouveau-né, Répartition par âge, Simulation numérique, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adolescent, Adult, Africa (epidemiology), Age Distribution, Aged, Aged, 80 and over, Animals, Anopheles (parasitology), Child, Child, Preschool, Computer Simulation, Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (prevention & control), Filaricides (administration & dosage), Filaricides (pharmacology), Humans, Infant, Infant, Newborn, Insect Vectors (parasitology), Middle Aged, Models, Biological, Software.
- MESH :
- chemical , administration & dosage : Filaricides.
- geographic , epidemiology : Africa.
- epidemiology : Elephantiasis, Filarial.
- parasitology : Anopheles, Insect Vectors.
- chemical , pharmacology : Filaricides.
- prevention & control : Elephantiasis, Filarial.
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Animals, Child, Child, Preschool, Computer Simulation, Humans, Infant, Infant, Newborn, Middle Aged, Models, Biological, Software.
Abstract
LYMFASIM is a simulation model for lymphatic filariasis transmission and control. We quantified its parameters to simulate Wuchereria bancrofti transmission by Anopheles mosquitoes in African villages, using a wide variety of reported data. The developed model captures the general epidemiological patterns, but also the differences between communities. It was calibrated to represent the relationship between mosquito biting rate and the prevalence of microfilariae (mf) in the human population, the age-pattern in mf prevalence, and the relation between mf prevalence and geometric mean mf intensity. Explorative simulations suggest that the impact of mass treatment depends strongly on the mosquito biting rate and on the assumed coverage, compliance and efficacy. Our sensitivity analysis showed that some biological parameters strongly influence the predicted equilibrium pre-treatment mf prevalence (e.g. the lifespan of adult worms and mf). Other parameters primarily affect the post-treatment trends (e.g. severity of density dependence in the mosquito uptake of infection from the human blood, between-person variability in exposure to mosquito bites). The longitudinal data, which are being collected for evaluation of ongoing elimination programmes, can help to further validate the model. The model can help to assess when ongoing elimination activities in African populations can be stopped and to design surveillance schemes. It can be a valuable tool for decision making in the Global Programme to Eliminate Lymphatic Filariasis.
Url:
DOI: 10.1017/S0031182008000437
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 005707
- to stream Istex, to step Curation: 005707
- to stream Istex, to step Checkpoint: 001085
- to stream PubMed, to step Corpus: 003089
- to stream PubMed, to step Curation: 003089
- to stream PubMed, to step Checkpoint: 003089
- to stream Ncbi, to step Merge: 003065
- to stream Ncbi, to step Curation: 003065
- to stream Ncbi, to step Checkpoint: 003065
- to stream Main, to step Merge: 006F35
- to stream Main, to step Curation: 006E26
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">LYMFASIM, a simulation model for predicting the impact of lymphatic filariasis control: quantification for African villages</title><author><name sortKey="Stolk, Wilma A" sort="Stolk, Wilma A" uniqKey="Stolk W" first="Wilma A." last="Stolk">Wilma A. Stolk</name></author><author><name sortKey="De Vlas, Sake J" sort="De Vlas, Sake J" uniqKey="De Vlas S" first="Sake J." last="De Vlas">Sake J. De Vlas</name></author><author><name sortKey="Borsboom, Gerard J J M" sort="Borsboom, Gerard J J M" uniqKey="Borsboom G" first="Gerard J. J. M." last="Borsboom">Gerard J. J. M. Borsboom</name></author><author><name sortKey="Habbema, J Dik F" sort="Habbema, J Dik F" uniqKey="Habbema J" first="J. Dik F." last="Habbema">J. Dik F. Habbema</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B93652CDF82FE70D5118A7E8844A24361D2E02D7</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1017/S0031182008000437</idno><idno type="url">https://api.istex.fr/document/B93652CDF82FE70D5118A7E8844A24361D2E02D7/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">005707</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">005707</idno><idno type="wicri:Area/Istex/Curation">005707</idno><idno type="wicri:Area/Istex/Checkpoint">001085</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001085</idno><idno type="wicri:doubleKey">0031-1820:2008:Stolk W:lymfasim:a:simulation</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:19006602</idno><idno type="wicri:Area/PubMed/Corpus">003089</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003089</idno><idno type="wicri:Area/PubMed/Curation">003089</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003089</idno><idno type="wicri:Area/PubMed/Checkpoint">003089</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003089</idno><idno type="wicri:Area/Ncbi/Merge">003065</idno><idno type="wicri:Area/Ncbi/Curation">003065</idno><idno type="wicri:Area/Ncbi/Checkpoint">003065</idno><idno type="wicri:Area/Main/Merge">006F35</idno><idno type="wicri:Area/Main/Curation">006E26</idno><idno type="wicri:Area/Main/Exploration">006E26</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">LYMFASIM, a simulation model for predicting the impact of lymphatic filariasis control: quantification for African villages</title><author><name sortKey="Stolk, Wilma A" sort="Stolk, Wilma A" uniqKey="Stolk W" first="Wilma A." last="Stolk">Wilma A. Stolk</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Public Health, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam</wicri:regionArea><wicri:noRegion>3000 CA Rotterdam</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Pays-Bas</country></affiliation></author><author><name sortKey="De Vlas, Sake J" sort="De Vlas, Sake J" uniqKey="De Vlas S" first="Sake J." last="De Vlas">Sake J. De Vlas</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Public Health, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam</wicri:regionArea><wicri:noRegion>3000 CA Rotterdam</wicri:noRegion></affiliation></author><author><name sortKey="Borsboom, Gerard J J M" sort="Borsboom, Gerard J J M" uniqKey="Borsboom G" first="Gerard J. J. M." last="Borsboom">Gerard J. J. M. Borsboom</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Public Health, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam</wicri:regionArea><wicri:noRegion>3000 CA Rotterdam</wicri:noRegion></affiliation></author><author><name sortKey="Habbema, J Dik F" sort="Habbema, J Dik F" uniqKey="Habbema J" first="J. Dik F." last="Habbema">J. Dik F. Habbema</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Public Health, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam</wicri:regionArea><wicri:noRegion>3000 CA Rotterdam</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Parasitology</title><title level="j" type="abbrev">Parasitology</title><idno type="ISSN">0031-1820</idno><idno type="eISSN">1469-8161</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="2008">2008</date><biblScope unit="volume">135</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="1583">1583</biblScope><biblScope unit="page" to="1598">1598</biblScope></imprint><idno type="ISSN">0031-1820</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0031-1820</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Africa (epidemiology)</term><term>Age Distribution</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Anopheles (parasitology)</term><term>Child</term><term>Child, Preschool</term><term>Computer Simulation</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Filaricides (administration & dosage)</term><term>Filaricides (pharmacology)</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Insect Vectors (parasitology)</term><term>Middle Aged</term><term>Models, Biological</term><term>Software</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Afrique (épidémiologie)</term><term>Animaux</term><term>Anopheles (parasitologie)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Filaricides (administration et posologie)</term><term>Filaricides (pharmacologie)</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (épidémiologie)</term><term>Humains</term><term>Logiciel</term><term>Modèles biologiques</term><term>Nourrisson</term><term>Nouveau-né</term><term>Répartition par âge</term><term>Simulation numérique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Vecteurs insectes (parasitologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Filaricides</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Africa</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Anopheles</term><term>Vecteurs insectes</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Anopheles</term><term>Insect Vectors</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Filaricides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Afrique</term><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Distribution</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Computer Simulation</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Middle Aged</term><term>Models, Biological</term><term>Software</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Filariose lymphatique</term><term>Humains</term><term>Logiciel</term><term>Modèles biologiques</term><term>Nourrisson</term><term>Nouveau-né</term><term>Répartition par âge</term><term>Simulation numérique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">LYMFASIM is a simulation model for lymphatic filariasis transmission and control. We quantified its parameters to simulate Wuchereria bancrofti transmission by Anopheles mosquitoes in African villages, using a wide variety of reported data. The developed model captures the general epidemiological patterns, but also the differences between communities. It was calibrated to represent the relationship between mosquito biting rate and the prevalence of microfilariae (mf) in the human population, the age-pattern in mf prevalence, and the relation between mf prevalence and geometric mean mf intensity. Explorative simulations suggest that the impact of mass treatment depends strongly on the mosquito biting rate and on the assumed coverage, compliance and efficacy. Our sensitivity analysis showed that some biological parameters strongly influence the predicted equilibrium pre-treatment mf prevalence (e.g. the lifespan of adult worms and mf). Other parameters primarily affect the post-treatment trends (e.g. severity of density dependence in the mosquito uptake of infection from the human blood, between-person variability in exposure to mosquito bites). The longitudinal data, which are being collected for evaluation of ongoing elimination programmes, can help to further validate the model. The model can help to assess when ongoing elimination activities in African populations can be stopped and to design surveillance schemes. It can be a valuable tool for decision making in the Global Programme to Eliminate Lymphatic Filariasis.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Stolk, Wilma A" sort="Stolk, Wilma A" uniqKey="Stolk W" first="Wilma A." last="Stolk">Wilma A. Stolk</name></noRegion><name sortKey="Borsboom, Gerard J J M" sort="Borsboom, Gerard J J M" uniqKey="Borsboom G" first="Gerard J. J. M." last="Borsboom">Gerard J. J. M. Borsboom</name><name sortKey="De Vlas, Sake J" sort="De Vlas, Sake J" uniqKey="De Vlas S" first="Sake J." last="De Vlas">Sake J. De Vlas</name><name sortKey="Habbema, J Dik F" sort="Habbema, J Dik F" uniqKey="Habbema J" first="J. Dik F." last="Habbema">J. Dik F. Habbema</name><name sortKey="Stolk, Wilma A" sort="Stolk, Wilma A" uniqKey="Stolk W" first="Wilma A." last="Stolk">Wilma A. Stolk</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006E26 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 006E26 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:B93652CDF82FE70D5118A7E8844A24361D2E02D7
|texte= LYMFASIM, a simulation model for predicting the impact of lymphatic filariasis control: quantification for African villages
}}
| This area was generated with Dilib version V0.6.31. |  |